SupplementGraded

Supplement Ingredient Guide

Evidence-based profiles for common supplement ingredients. Understand what works, what doesn't, proper dosing, safety concerns, and which forms to look for.

Minerals(3)Vitamins(2)Fatty Acids(1)Probiotics(1)Adaptogens(1)Sports Nutrition(1)Herbs(1)

Vitamin D3 (Cholecalciferol)

Vitamins

Vitamin D3 is the most bioavailable form of vitamin D, produced naturally in the skin upon sun exposure. It plays a critical role in calcium absorption, bone health, immune function, and mood regulation.

CholecalciferolCalcifediol4 interactions

Magnesium

Minerals

Magnesium is involved in over 300 enzymatic reactions in the body. It supports muscle and nerve function, blood sugar control, blood pressure regulation, and protein synthesis. An estimated 50% of Americans don't get adequate magnesium.

Magnesium glycinateMagnesium threonate4 interactions

Omega-3 Fatty Acids (EPA/DHA)

Fatty Acids

Omega-3 fatty acids EPA and DHA are essential fats that the body cannot produce on its own. They are critical for brain health, heart health, and reducing inflammation throughout the body.

Triglyceride form fish oilEthyl ester3 interactions

Probiotics

Probiotics

Probiotics are live beneficial bacteria that support gut health, immune function, and nutrient absorption. Different strains serve different purposes — Lactobacillus and Bifidobacterium are the most researched genera.

Multi-strain formulasDelayed-release capsules2 interactions

Ashwagandha (Withania somnifera)

Adaptogens

Ashwagandha is an adaptogenic herb used in Ayurvedic medicine for over 3,000 years. It's primarily used to reduce stress and anxiety, improve sleep, and support hormonal balance. Clinical trials show it significantly reduces cortisol levels.

KSM-66Sensoril4 interactions

Zinc

Minerals

Zinc is an essential trace mineral involved in immune function, protein synthesis, wound healing, and DNA synthesis. It's one of the most common deficiencies worldwide, especially in vegetarians and the elderly.

Zinc picolinateZinc glycinate4 interactions

Creatine Monohydrate

Sports Nutrition

Creatine is the most researched sports supplement in history with over 500 studies supporting its safety and efficacy. It increases phosphocreatine stores in muscles, improving high-intensity exercise performance, strength, and recovery.

Creatine monohydrate2 interactions

Turmeric / Curcumin

Herbs

Curcumin is the active compound in turmeric responsible for its anti-inflammatory properties. Standalone turmeric has very low bioavailability (2-3%), so supplements typically use enhanced absorption formulations with piperine or lipid-based delivery.

Curcumin with piperine/BioPerineMeriva3 interactions

Iron

Minerals

Iron is essential for oxygen transport in blood (hemoglobin) and muscle (myoglobin). Iron deficiency is the most common nutritional deficiency worldwide. However, excess iron is toxic and supplementation should be based on documented need.

Iron bisglycinateFerrous sulfate5 interactions

Vitamin B12 (Cobalamin)

Vitamins

Vitamin B12 is essential for nerve function, red blood cell formation, and DNA synthesis. Deficiency is common in vegans, the elderly, and those on metformin or proton pump inhibitors. The body can store years' worth of B12, so deficiency develops slowly.

MethylcobalaminAdenosylcobalamin4 interactions